Gene information
Official symbol GRK2
Official full name G protein-coupled receptor kinase 2
Gene type protein-coding gene
Chromosome11q13.2
Alias symbolBARK1
Previous symbolADRBK1
Gene familyPleckstrin homology domain containing; AGC family kinases
Resources
Entrez Gene 156
HGNC HGNC:289
Ensembl ENSG00000173020
Vega OTTHUMG00000167104
UCSC uc009yrn.2
GO terms: 39 records
GO Description Category LogP Number of genes Detail
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0002026 regulation of the force of heart contraction GO Biological Processes -7.48167444 7 More
GO:0002029 desensitization of G protein-coupled receptor signaling pathway GO Biological Processes -2.96024730 3 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006898 receptor-mediated endocytosis GO Biological Processes -6.77623895 13 More
GO:0006936 muscle contraction GO Biological Processes -17.3443769 27 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008277 regulation of G protein-coupled receptor signaling pathway GO Biological Processes -5.69311965 11 More
GO:0016301 kinase activity GO Molecular Functions -2.42130611 19 More
GO:0018107 peptidyl-threonine phosphorylation GO Biological Processes -1.81353228 3 More
GO:0018210 peptidyl-threonine modification GO Biological Processes -1.68016791 3 More
GO:0022401 negative adaptation of signaling pathway GO Biological Processes -2.96024730 3 More
GO:0023058 adaptation of signaling pathway GO Biological Processes -2.88014031 3 More
GO:0031623 receptor internalization GO Biological Processes -4.60359151 7 More
GO:0031690 adrenergic receptor binding GO Molecular Functions -4.18483678 6 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway GO Biological Processes -4.37747366 6 More
GO:0045932 negative regulation of muscle contraction GO Biological Processes -6.35549828 9 More
GO:0050433 regulation of catecholamine secretion GO Biological Processes -6.37680507 13 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051952 regulation of amine transport GO Biological Processes -10.5179624 22 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0095500 acetylcholine receptor signaling pathway GO Biological Processes -3.70345918 7 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098926 postsynaptic signal transduction GO Biological Processes -3.73790071 8 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1905144 response to acetylcholine GO Biological Processes -4.09043632 8 More
GO:1905145 cellular response to acetylcholine GO Biological Processes -3.51698265 7 More
Related studies: 9 records
Molecular factor Omics type Application Objective MI type Reference
GRK2 transcriptomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Gao WQ et al. J Geriatr Cardiol. 2013
GRK2 transcriptomics heart failure[prognosis (bad)] acute ST elevation myocardial infarction Gao WQ et al. J Geriatr Cardiol. 2013
beta-adrenergic receptor kinase 1 proteomics left ventricular dysfunction[prognosis (bad)] acute ST elevation myocardial infarction Santulli G et al. Am J Cardiol. 2011
beta-adrenergic receptor kinase 1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Santulli G et al. Am J Cardiol. 2011
beta-adrenergic receptor kinase 1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Gao WQ et al. J Geriatr Cardiol. 2013
beta-adrenergic receptor kinase 1 proteomics heart failure[prognosis (bad)] acute ST elevation myocardial infarction Gao WQ et al. J Geriatr Cardiol. 2013
beta-adrenergic receptor kinase 1 proteomics depression[prognosis (bad)] acute myocardial infarction Tian X et al. Neuropsychiatr Dis Treat. 2016
beta-adrenergic receptor kinase 1 proteomics paroxetine[treatment (pharmacotherapy)] acute myocardial infarction Tian X et al. Neuropsychiatr Dis Treat. 2016
beta-adrenergic receptor proteomics left ventricular dilation[prognosis (bad)] acute myocardial infarction Spyrou N et al. J Am Coll Cardiol. 2002
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